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Séminaire PLUM : vendredi 16 septembre 2022 à 11h00

Marcelo Kogan (University of Chile)


Titre : Gold nanoparticles for diagnostic and treatment of chronic diseases



Institut Néel, Salle F418
RésuméGold nanoparticles (GNPs) emerged as an interesting tool for different applications in biomedicine as drug delivery, diagnostic, therapy and for the so called theranostics which consist in the diagnostic and treatment of pathologies in a unique procedure (1,2). Some of the interesting properties of GNPs are the Surface Enhanced Fluorescence and Surface Raman Enhanced scattering effects and their photothermal capacity that allow use them for diagnostics and therapy, respectively. For targeting purposes GNPs could be functionalized with multiple functional moieties as peptides capable of selective targeting, imaging, and delivery of specific drugs to target malignant cells and amyloid toxic aggregates (3,4,5).
In the seminary will be discussed studies related with the  functionalization of GNPs and their interaction with different biological targets. Moreover, we will talk about the potential use of GNPs for cancer (3), cardiovascular (6) and Alzheimer’s diseases in relation with drug delivery, diagnostic, therapy and theranostics (1) considering also their potential risks.
1.Biomaterials science 9, 11, 4178 (2021) DOI10.1039/d0bm01825b
2.Journal of Nanobiotechnology 18, 20 (2020) DOI 10.1186/s12951-020-0573-0
3.Pharmaceutics 14, 5. (2022) DOI 10.3390/pharmaceutics14050958
4.Chemical society reviews 51, 7, 2601 (2022) DOI 10.1039/d1cs01111a
5.Nanomedicine: Nanotechnology, Biology and Medicine 44, 102569 (2022) DOI 10.1016/j.nano.2022.102569
6.Journal of Controlled Release 328, 859 (2020) DOI10.1016/j.jconrel.2020.11.002