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Ultrabright Silica-Coated Organic Nanocrystals for Two-Photon In Vivo Imaging

Ultrabright fluorescent silica-coated organic nanocrystals containing a crystalline core of small push−pull dipolar dye were specifically designed to exhibit two-photon absorption for fluorescence imaging. These nanoparticles can be easily functionalized in pure water, with preservation of the organic core. A novel small-volume DLS technique was used to evaluate the effect of PEGylation on the colloidal stability in complex media containing salts and proteins, mimicking the composition of blood serum. The potential of these bright red-emitting nanoparticles for two-photon fluorescence imaging was demonstrated in vivo.

Shridevi Shenoi Perdoor,­­a Fabien Dubois, a* Aude Barbara, a Christophe Nguyen, b Lamiaa M. A. Ali,b,c Magali Gary-Bobo, b Ines Hristovska, d Kassandre Combet, d Olivier Pascual, d Guillaume Micouin,e Akos Banyasz, e Yann Bretonnière, e Chantal Andraud e Alain Ibanez­a and Xavier Cattoën, a*

a Univ. Grenoble Alpes, CNRS, Grenoble INP, Institut Néel, 38000 Grenoble, France.
b IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.
c Department of Biochemistry, Medical Research Institute, University of Alexandria, 21561 Alexandria, Egypt
d Institut NeuroMyoGène, Equipe Synaptopathies et Autoanticorps (SynatAc), INSERM U1217/UMR CNRS 5310/University of Lyon, Université Claude Bernard Lyon 1, Lyon, France.
e Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Lyon I, Laboratoire de Chimie, F-69342 Lyon, France

ACS Applied Nanomaterials, 2020, 3, 11933-11944

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