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My research is based on two topics:
1. the synthesis of silica nanoparticles for fluorescence bioimaging
2.The controlled aggregation of nanoparticles to develop new optical correlation spectroscopy experiments and for the development of new photocatalytic materials.
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We develop a home-made spray-drying reactor to synthesize self-organized organic crystal core@silica shell nanoparticles. The process is based on the nebulization of a sol containing a dye that present fluorescence at crystal state. After the formation of droplet and due to the heating process, we obtain nucleation and growth of a fluorescent organic crystal embedded inside a silica crust (figure 1). |
Figure 1 : spray-drying reactor and self-organization of core@shell NP during the heating treatment of droplet. |
This new type of core@shell nanoparticle present high fluorescence brightness, modulable fluorescence properties as a function of the select dye (figure 2) and easy surface functionalization to improve colloidal stability or targeting for in-vivo or in-vitro fluorescence imaging.
Figure 2 : fluorescence spectra of different core@shell nanoparticles and FESEM imaging of NP obtained
In the team, we developed a new home-made setup to performed Optical correlation spectroscopy measurements (light scattering, fluorescence or Raman fluctuation signal).
In order to enhance the non-elastic Raman signal. We developed the formation of controlled aggregate of Ag-NP induced by the addition of organic molecules. Organic molecules lying in the electromagnetic hot spots exhibit a high exaltation of the efficiency of Raman radiation. In this case, our setup enables us to determine quantitatively and in situ the size of SERS active clusters and to characterize the different states of aggregation during cluster formation.
a) absorption spectrum evolution during aggregation process of Ag-NPs. b) SERS sepctrum of organic molecules inside Ag-NP aggregates. c) Raman correlation spectra of different size of Ag-NP aggregat
Now, we develop some chemistry approach, such as click chemistry between functional ligands, to control the formation of aggregate systems and to develop these Optical correlation spectroscopies and also to develop new type of hybrid colloidal systems such as QD attached to Ag-NP for the development of new photocatalysis materials.
Most of my teaching activities are located at Grenoble university (UGA) in front of students of Licence or Master cycle.
Content: Lattice, unit cells, atoms stacking, octahedral and tetrahedral sites in FCC structures, metallic alloys, simple ionic structures.
Content: Chemical reaction mechanism (acid-base; oxydo-reduction; complexation), Stereochemistry (organometallic complexes, organic molecules), Intermolecular interactions, Reactivity in organic chemistry (description of the nucleophile substitution and the elimination reaction).
Content: acidic dosing, gravimetry, UV-Vis spectroscopy, potentiometry, redox dosing.
More detail concerning our formations in licence: https://dlst.univ-grenoble-alpes.fr/
I am involved in the master “ Nanosciences & nanotechnologies”. I offer in this master several lectures. I am also responsible for interdisciplinary practical work for which I develop original practical sessions related to nanosciences and in particular related to syntheses and colloidal properties of nanoparticles
More detail concerning our formations in nanosciences: https://master-nanosciences.univ-grenoble-alpes.fr/
Content: Introduction to colloidal systems (definition, colloidal stability and size characterization), porous materials: (Sorption and desorption phenomena).
Content: Metallic nanoparticles synthesis and properties, quantum dots synthesis and properties, introduction to electron microscopes.
Content: Silver nanoprism synthesis, kinetic of a nanoparticles aggregation.
Full list available on google scholar
[R17] In Situ Identification of Spherical Ag Monomers and Dimers at Zeptomole Adsorbate Concentrations by Surface-Enhanced Raman Scattering Correlation Spectroscopy, Aude Barbara, Fabien Dubois, Pascal Quémerais, ACS Omega, 2019, 4(1), 2283-2290.
[R16] Red-emitting fluorescent organic@silicate core-shell nanoparticles towards bio-imaging, Shridevi Shenoi-Perdoor, Xavier Cattoën, Yann Bretonnière, Chantal Andraud, Béatrice Gennaro, Stéphanie Kodjikian, Fabien Dubois and Alain Ibanez, New Journal of Chemistry, 2018, 42, 15353 – 15360
[R15] NIR-to-NIR two photon scanning laser microscopy imaging of single nanoparticles doped by Yb(III) complexes. A. Bourdolle, A. D’Aléo, C. Philippot, P. L. Baldeck, Y. Guyot, F. Dubois, A. Ibanez, C. Andraud, S. Brasselet, O. Maury. Chem.Phys.Chem., 2016, 17(1), 128-135.
[R14] SERS correlation spectroscopy of silver aggregates in Colloidal suspension: quantitative sizing down to a single nanoparticle. A. Barbara, F. Dubois, A. Ibanez, L. Eng, P. Quémerais, J. Phys. Chem. C, 2014, 118(31), 17922-17931.
[R13] Polymorphism of CMONS nanocrystals grown in silicate particles through a spray-drying process. C. Philippot, J. Zimmermann, F. Dubois, M. Bacia, B. Boury, P. L. Baldeck, S. Brasselet, A. Ibanez. Crystal Growth & Design, 2013, 13(12), 5241-5248.
[R12] Non-resonant and non-enhanced Raman correlation spectroscopy. A. Barbara, F. Dubois, P. Quémerais, L. Eng., Optics express, 2013, 21(13), 15418-15429.
[R11] Core-shell and doped silicate nanoparticles prepared by a spray-drying process for the development of biological luminescent tracers. C. Philippot, F. Dubois, A. Bourdolle, O. Maury, B. Boury, C. Andraud, A. Ibanez. Nonlinear optics and quantum optics, 2012, 45(1-2), 141-151.
[R10] New core-shell hybrid nanoparticles for biophotonics: fluorescent organic nanocrystals confined in organosilicate spheres, C. Philippot, F. Dubois, M. Maurin, B. Boury, A. Prat, A. Ibanez, J. Mat. Chem., 2012, 22(22), 11370-11378.
[R9] Doped silica nanoparticles containing two-photon luminescent Eu(III) complexes for the development of water stable bio-labels, C. Philippot, A. Bourdolle, O. Maury, F. Dubois, B. Boury, S. Brustlein, S. Brasselet, C. Andraud, A. Ibanez, J. Mat. Chem., 2011, 21, 18613-18622.
[R8] In situ electron-beam polymerization stabilized quantum dot micelles. Nathalie Travert-Branger, Fabien Dubois, Jean-Philippe Renault, Serge Pin, Benoït Mahler, Edmond Gravel, Benoït Dubertret, Eric Doris, Langmuir, 2011, 27(8), 4358-4361.
[R7] Oligomeric PEG-phospholipids for solubilization and stabilization of fluorescent nanocrystals in water, Nathalie Travert-Branger, Fabien Dubois, Olivier Carion, Geraldine Carrot, Benoït Mahler, Benoït Dubertret, Eric Doris, and Charles Mioskowski, Langmuir, 2008, 24, 3016-3019
[R6] Simultaneous determination of cadmium (II) and zinc (II) by molecular fluorescence spectroscopy and multiple linear regression using an anthrylpentaazamacrocycle chemosensor, S. Yunus, S. Charles, F. Dubois, E. Vander Donckt, Journal of Fluorescence, 2008, 18, 499–506
[R5] A versatile strategy for quantum dots ligand exchange. Fabien Dubois, Benoit Malher, Benoit Dubertret, Eric Doris et Charles Mioskowski, J. Am. Chem. Soc., 2007, 129, 482-483.
[R4] Integrated luminometer for the determination of trace metals in seawater using fluorescence, phosphorescence and chemiluminescence detection. P. J. Worsfold, E.P. Achterberg, A. R. Bowie, V. Cannizzaro, S. Charles, J. M. Costa, F. Dubois, R. Perreiro, B. San Vicente, A. Sanz-Medel, R. Vanderloise, E. Vander Donckt, P. Wollast, S. Yunus, Journal of Automated Methods and Management in Chemistry, 2002, 24, 41-47.
[R3] Determination of cadmium in marine waters. On-line preconcentration and flow-through fluorescence detection. S. Charles, S. Yunus, F. Dubois, E. Vander Donckt, Analytica Chimica Acta, 2001, 440, 37-43.
[R2] Synthesis of Carbohelicenes and Derivatives by Carbenoid Coupling. M. Gingras, F. Dubois, Tetrahedron Letters, 1999, 40(7), 1309-1312.
[R1] Syntheses of [5]-Helicene by McMurry or Carbenoid Coupling. M. Gingras, F. Dubois, Tetrahedron Letters, 1998, 39(28), 5039-5040.
[P4] Formation en nanosciences et nanotechnologies : un pas vers une « vraie » interdisciplinarité. H. Sellier, E. Planus, F. Dubois, L. Lévy, I. Gautier-Luneau, P. Peyla, F. Marchi, J3EA, 2014, 13, 003.
[P3] Multifunctional hybrid nanoparticles for two-photon fluorescence imaging and photodynamic therapy. P. Baldeck, M. Maurin, C. Philippot, S. Zaiba, T. Gallavardin, O. Maury, C. Andraud, F. Dubois, A. Ibanez, F. Lerouge, S. Parola, O. Stephan, B. Van Der Sanden. Book Series: Proceedings of SPIE- Organic photonic materials and devices XIII. Volume: 7935, 2011.
[P2] Fluorescent organic nanocrystal confined in sol-gel matrix for bio-imaging. C. Philippot, F. Dubois, M. Bacia, E. Djurado, A. Ibanez, Conference Information: 15th International Sol-Gel Conference (SOLGEL 2009), AUG 23-27, 2009 Porto de Galinhas, BRAZIL, J. Sol-gel Sci. Technol., 2011, 57, 253-257.
[P1] Determination by fluorescence spectroscopy of cadmium at sub-nanomolar level – Application to seawater. S. Charles, F. Dubois, S. Yunus, E. Vander Donckt, 11th Meeting on Euroanalysis XI, Lisbon, Portugal, SEP 03-09, 2000, Journal of Fluorescence, 2000, 10, 99-105.
[B1] Click Functionalization of Sol–Gel Materials. S. Shenoi-Perdoor, A Noureddine, F. Dubois, M. Wong Chi Man, X. Cattoën, Handbook of Sol-gel Science and technology, 2016, 1-40.
Department: PLUM
Team: Optics and Materials (OPTIMA)
Status: Personnel Chercheur
Structure: UGA
Position: Permanent
Email: fabien.dubois@neel.cnrs.fr
Phone: 04 76 88 74 10
Office: F-306
