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Séminaire MCBT

Mardi 22 novembre à 11h00,
Salle Louis Weil, E424

Orateur : Clothilde COILHAC, PhD, Neel
"Thermodynamic of the self-assembly of DNA nanostructures"


The self-assembly property of the DNA helix allows the use of DNA as a building block for the assembly of nanostructures. Many 2D or 3D structures have been assembled but little is known about the folding process. This knowledge would enable us to optimize and rationalize the design of such structures.

Our approach is to study the folding of model structures (tetrahedron, rectangle origami) to identify the thermodynamically intermediates states. We explore the energy landscape in order to understand the general mechanisms leading these systems towards their minimum free energy.

However, these calorimetric measurements require a large amount of DNA. That is why we develop in parallel a calorimetric sensor integrating microfluidic on a membrane to perform ITC experiment (isothermal titration calorimetry) on volume from 1000 to 10000 times smaller.

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