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Séminaire MCMF

Vendredi 12 décembre à 11h00,
Salle Erwin Bertaut, F418

Orateur : Jean-Olivier Durand (Institut Charles Gerhardt, Montpellier)
"Mesoporous silica and mesoporous silicon Nanoparticles for drug delivery and two-photon Photodynamic Therapy"

Abstract
Mesoporous silica nanoparticles (MSN) have attracted much attention the last decade for nanomedicine applications due to their biocompatibility, flexible functionalisation, tunable pore size and diameter. We describe here MSN engineered for two-photon triggered drug delivery or photodynamic therapy, in MCF-7 breast cancer cells. The two-photon triggered drug delivery system was based on a FRET mechanism from a two-photon dye in the walls of the MSN to an azobenzene moiety in the pores of the MSN (nanoimpellers). Concerning photodynamic therapy, a two-photon photosensitizer was encapsulated in the walls of the MSN. Two-photon photodynamic therapy was performed in vitro and in vivo on mice bearing colon xenografted tumors. We also studied the use of porous silicon nanoparticles (pSiNP) functionalized with both a photosensitizer and a targeting agent. Porous silicon is a biocompatible and biodegradable material which can generate 1O2 when excited by visible light due to quantum-confinement effect. pSiNP had been shown to be degraded into non-toxic silicic acid byproducts in vivo. The multi-functionalized pSiNP studied here were able to target, image and kill cancer cells in vitro by photodynamic therapy mechanisms both with 1-photon and 2-photon excitation.

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