Neural architecture

The field of neurosciences constitutes a natural playground for physicists and engineers. Historically, this is illustrated by the emergence of electrophysiology as an independent discipline and by the continuous implementation of up-to-date technologies for neuronal interfacing. This instrumental aspect is however not the only territory where micro-electronic and neuroscience can advantageously meet. Recording neuronal activity implies to understand and ultimately to control the nature and the properties of the neuron/electronic interface. A new field in itself, highly multi-disciplinary, has thus emerged from the basic requirements to create neuronal in vitro architectures and to optimize the neuron-electrode interface. Its aim is to explore the neuron, and more globally the brain cell responses to the chemical and topographic properties of the micro-environment. As a result, the electrical picture of neurons has been enriched by many biophysical aspects, related for example to biomechanics and more generally to the cytoskeleton structure and dynamics in controlled environments. (... more details here)

S. Roth, G. Bugnicourt, M. Bisbal, S. Gory-Fauré, J. Brocard, and C. Villard, "Neuronal Architectures with Axo-dendritic Polarity above Silicon Nanowires", Small 8, 671-675 (2012). (link)

S. Roth, M. Bisbal, J. Brocard, G. Bugnicourt, A. Andrieux, S. Gory-Faure, and C. Villard, "How morphological constraints affect axonal polarity in mouse neurons", Plos One, 7(3):e33623, 2012. (link)

G. Bugnicourt, J. Brocard, A. Nicolas, A. and C. Villard, "Nanoscale surface topography reshapes neuronal growth in culture", Langmuir, 30(15), 4441-4449 (2014). (link)

C. Tomba, C. Braïni, B. Wu, N.S. Gov and C. Villard, "Tuning the adhesive geometry of neurons: length and polarity control", Soft matter, 10(14), 2381-2387 (2014). (pdf)

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